William Fichtner
Eric Sacks

Danny Woodburn
Splinter

Johnny Knoxville
Leonardo (voice)

Tony Shalhoub
Splinter (voice)

Tohoru Masamune
Shredder

Whoopi Goldberg
Bernadette Thompson

Minae Noji
Karai

Abby Elliott
Taylor

Madison Mason
Councilman

Taran Killam
McNaughton