Det. Reno Raines becomes a fugitive from justice when his investigation of illicit police activity leads a corrupt lieutenant to frame him for murder.

Reno runs a bully (Pete Koch) out of a small town, but the man spots Reno's picture on a wanted poster and informs the police of his whereabouts.

Reno races the police to capture a hired killer in order to determine if the man has information on Reno's case--and to stop him from murdering a judge.

Reno takes on a group of Salvadorian assassins.

Reno is sent out to find the man who killed Jimmy, a motorcycle mechanic and finds himself in a small desert town. The town is run by a rich businessman who even has the local lawn under his control. Reno finds a biker club and infiltrates to find his killer.

Lou Delgado, a real estate con man, is arrested then bailed out by her girlfriend, Jeanette. Lou decides to cut his losses and leave town, only to end up being a witness to a shooting.

In the middle of a huge storm, Reno stops at a seemingly deserted diner in a small town, but the place is taken hostage by escaped prisoners with a grudge to settle with the diner owner, who sold them out in prison.

Two bloodthirsty killers shoot an informant friend of Reno's and give Reno himself a savage beating that leaves him hospitalized. Reno goes undercover at the ranch where one of the duo's ex-wife works, to try and get a lead on the pair, determined to get even.

Reno is close to capturing a vicious killer, when he encounters a feisty teenage girl, who is after the man herself after he murdered her FBI agent father. Reno reluctantly joins forces with the girl, but her hot-headedness jeopardizes the whole case.

After reading in the Newspaper about the trgic death of his ex-mentor/partner Reno seeks information as to what had caused his ex-partners death.He is informed by one policeman that an infamous drug dealer was responsible.The drug dealer one Jesus Ortega had escaped to Mexico.Reno accompanied by Bobby heads for Mexico for two purposes: Justice,and Revenge.

Reno sets out to bring in Earl Lyons, a former comrade from Reno's Army Ranger days, who now is addicted to morphine and has gone insane, living in the wilderness. Reno must stop Lyons before either the trigger-happy authorities, or drug runners whom Lyons double-crossed, get to him first.

A bullet that was meant for Reno critically injured his girlfriend Valerie instead. After spending months in coma, she is finally released from her suffering. The criminal lieutenant Donald "Dutch" Dixon places a trap for Reno: He lets spreads the news that Valerie is healed.

Reno helps a woman with a flat tire in the desert. Soon after that the woman is found dead in her home.

Reno Raines is about to arrest the gangster franc sand when he becomes a witness, as a small Japanese girl is kidnapped.

Lieutenant Dixon and Frank Bickford think of a plan to finally capture Reno: They release a criminal Tommy, who looks just like Reno.

Reno is to snatch in a the gangster Dad Meecham and his three sons. While a brawl in the Saloon the sons become arrested, Meecham however can escape.

Joe Cortez had sworn revenge with his arrest. He breaks out of prison and procures himself weapons and money.

Reno is to bring Amber Dane, a Hollywood Starlet, before court. Reason: Amber allegedly killed her friend five years before .

Reno helps out a man being attacked in the middle of the road. The man takes Reno home with him to Second Chance Farms: a place where ex-criminals who want to begin a new life are able to work.

The daughter of Reno's loyal long-time friend Assistant D. A. Wells begins going on a downhill spiral, entering a life of drug addiction. Upon further investigation, Reno and Cheyenne discover there is much more to this family tragedy than originally thought. They soon uncover a rather elaborate scheme involving black market drugs, a touring rock band, and a corrupt band manager who plans to use the girl to leverage Wells into dropping the impending case against her brother, a notorious drug dealer.

Reno receives a video tape as proof that his estranged brother Mitch is still alive, despite being declared dead in Vietnam by the military many years prior. The video tape depicts Mitch competing in a rather sketchy underground cage fighting tournament. Reno decides to enter this strange underground world and investigate his brother's disappearance by posing as one of the fighters. He soon discovers that his brother has been brainwashed, and rescuing him from this dangerous and barbaric lifestyle will not be quite as easy as he once thought.

After having some success in the preliminary rounds of the tournament, Reno begins to make some progress with helping his brother Mitch regain his memory. This becomes easier once he slowly starts having flashbacks of childhood memories of the two. Eventually Mitch joins Reno's side. The two bring down the entire cage fighting circus and those who conduct it, with the help of Bobby Sixkiller and a special task force.